Journal: Acta Neuropathologica Communications
Article Title: Dual targeting of iNOS and Src tyrosine kinase as a superior therapeutic strategy against soman-induced long-term neurotoxicity: multimodal biomarker, imaging, and neurobehavioral outcome analyses
doi: 10.1186/s40478-025-02220-8
Figure Lengend Snippet: Motor behavioral assessment and its correlation with rsFC of different brain networks post-soman exposure. a A Rotarod (RR) apparatus was used to test the motor behavior of rats at 6 weeks post-soman. The time to fall for each animal is plotted as mean ± SEM in ( b ) and as difference in mean compared to control in ( c ), depicted as a horizontal line. * indicates the soman effect (soman vs control) and # represents treatment effect (vs soman + vehicle). d , e A correlation matrix depicting a correlation coefficient (Pearson correlation, p < 0.05) between time to fall (seconds) in RR (6 weeks post soman) and rsFC of different regional networks (8–9 weeks post soman) is presented, with ‘X’ marks p -value ≥ 0.05 (not significant). f – i Simple linear regression comparing between the time to fall (seconds) and the rsFC (active voxels) with the corresponding correlation coefficient (r) and p -value. Each dot on the graphs represents a data point from each animal. n = 15–30 (7–16/sex), * indicates soman effect (vs control) and # represents effect (vs Soman + vehicle) with corresponding p -values
Article Snippet: Motor learning and coordination in rodents were assessed using an accelerating rotarod apparatus (AccuRotor 4-channel, Omnitech Electronics Inc., and Start Fusion v6.2 AccuRotor Edition Software) as previously described [ ].
Techniques: Control